What question did this study set out to answer?

The research aims to develop a portable optical fiber probe for high-sensitivity molecular interaction sensing.

March 1, 2026

Microfluidic-Free Surface Plasmonic Lattice Resonance Fiber Probe Enabled Portable Molecular Interaction Sensing

Puntos clave

The research aims to develop a portable optical fiber probe for high-sensitivity molecular interaction sensing.
Integrated a non-close-packed gold nanoparticle array on the fiber endface.
Utilized a coaxial optical design for direct immersion in liquids.
Conducted DNA hybridization experiments to test sensitivity.
Achieved a detection limit of 10 nM for molecular interactions.
Enhanced refractive-index sensitivity through surface plasmonic lattice resonance.
Provided a new strategy for high-performance plasmonic sensors.

Resumen

Balancing high sensitivity and detection efficiency is a key challenge in plasmonic molecular sensing. We report a portable surface plasmonic lattice resonance (SLR) optical fiber probe integrating a non-close-packed gold nanoparticle array on the fiber endface. Its coaxial optical design allows direct immersion in liquids, removing complex microfluidics and boosting efficiency. The high refractive-index sensitivity of SLRs enables the sensitive monitoring of molecular interactions. DNA hybridization experiments show a detection limit of 10 nM. This work establishes a practical strategy for integrating high-performance plasmonic nanostructures with optical fiber platforms and provides a promising route toward high-sensitivity portable biochemical sensors.

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Cite This Study

Li et al. (Fri,) studied this question.

synapsesocial.com/papers/69a3d7baec16d51705d2df2b https://doi.org/https://doi.org/10.1021/acsaom.6c00018

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