Preoperative Edmonton Frail Scale independently predicted 30-day postoperative complications (OR 1.284, p=0.006) and mortality (OR 1.323, p=0.014) in patients ≥65 undergoing colorectal cancer surgery.
Observational (n=200)
No
Does the Edmonton Frail Scale (EFS) independently predict 30-day postoperative complications and mortality in older adults undergoing elective colorectal cancer surgery?
Preoperative frailty assessment using the Edmonton Frail Scale provides excellent discrimination for predicting 30-day postoperative complications and mortality in older adults undergoing colorectal cancer surgery.
Estimación del efecto: OR 1.284 for postoperative complications per 1-point increase in EFS; OR 1.323 for mortality per 1-point increase in EFS (95% CI Complications 95% CI 1.075-1.535; Mortality 95% CI 1.060-1.652)
valor p: p=0.006 for complications; 0.014 for mortality
Frailty is associated with adverse surgical outcomes in older adults. We evaluated whether the Edmonton Frail Scale (EFS) is independently associated with 30-day postoperative morbidity and mortality after major colorectal cancer surgery. This prospective observational study enrolled patients aged ≥ 65 years undergoing elective oncologic colorectal resection (March–September 2025). Patients were stratified into five EFS frailty categories. The primary outcomes were 30-day postoperative complications (Clavien–Dindo; Grade I–II vs Grade III–V) and 30-day all-cause mortality. Associations were assessed using ROC analysis and multivariable logistic regression. Of 205 enrolled patients, 200 were analyzed (63% male; median age 70 years). Thirty-day postoperative complications occurred in 40 patients (20%), and 30-day mortality was 5% (10/200). EFS was associated with longer hospital length of stay and higher complication and mortality rates. EFS showed excellent discrimination for postoperative complications (AUC 0.928; 95% CI 0.886–0.970), with an optimal cut-off of ~ 6.5 (sensitivity 96.2%, specificity 76.9%). In multivariable models, EFS remained independently associated with complications (OR 1.284; p = 0.006) and mortality (OR 1.323; p = 0.014). Preoperative EFS provides independent and clinically meaningful prediction of 30-day morbidity and mortality after major colorectal cancer surgery in older adults and may enhance perioperative risk stratification and shared decision-making. NCT06866678 and registration on 05 March 2025.
Sahin et al. (Fri,) conducted a observational in Older adults (≥65 years) undergoing elective oncologic colorectal resection for colorectal cancer (n=200). Preoperative Edmonton Frail Scale (EFS) assessment was evaluated on 30-day postoperative complications (medical and surgical, Clavien-Dindo Grade I-V) and 30-day all-cause mortality (OR 1.284 for postoperative complications per 1-point increase in EFS; OR 1.323 for mortality per 1-point increase in EFS, 95% CI Complications 95% CI 1.075-1.535; Mortality 95% CI 1.060-1.652, p=0.006 for complications; 0.014 for mortality). Preoperative Edmonton Frail Scale independently predicted 30-day postoperative complications (OR 1.284, p=0.006) and mortality (OR 1.323, p=0.014) in patients ≥65 undergoing colorectal cancer surgery.