A humanized NOG-EXL mouse model for producing severe fever with thrombocytopenia syndrome virus-reactive human antibodies.

Puntos clave

• The aim is to develop a humanized mouse model for studying severe fever with thrombocytopenia syndrome virus and its human antibody response.
• Created a humanized NOG-EXL mouse model
• Evaluated humoral immunity against the virus
• Isolated B cells for high-affinity human monoclonal antibodies
• Avoided genetic engineering in the process
• Demonstrated effective humoral immune response in the model
• Facilitated isolation of specific human antibodies without genetic modifications
• Provided a platform for further studies on antibody functionality