Pancreatic neuroendocrine tumors (PanNETs) are increasingly diagnosed, reflecting greater clinical awareness, improved imaging, and revised classification. This review summarizes evidence on epidemiology, diagnostic workup, and endoscopic ultrasound (EUS)-guided management of PanNETs, encompassing diagnostic evaluation, tissue acquisition, and therapeutic interventions. EUS provides the highest diagnostic yield for lesions 177Lu]-Lu-DOTATATE appears to facilitate resection, but its optimal role remains to be defined. Emerging artificial intelligence and radiomics models using EUS images may refine risk stratification and support a precision endoscopy paradigm in PanNETs.
Bruni et al. (Thu,) studied this question.