What question did this study set out to answer?

This study aims to compare pain management strategies and their outcomes in non-operatively treated patients with multiple rib fractures.

March 1, 2026Open Access

Pain management in non-operatively treated patients with multiple single rib fractures: an international comparison

Puntos clave

This study aims to compare pain management strategies and their outcomes in non-operatively treated patients with multiple rib fractures.
Retrospective cohort design including patients ≥ 18 years with ≥ 3 single rib fractures.
Conducted at Massachusetts General Hospital and Leiden University Medical Center between 2018 and 2023.
Primary outcomes included pain score change, opioid use at discharge, and pulmonary complications.
Subgroup analyses evaluated fracture side, displacement, and ICU admission.
Logistic regression identified predictors of pneumonia.
545 patients were included, with 109 from Leiden University Medical Center.
LUMC patients were younger with fewer comorbidities but higher injury severity scores.
LUMC favored patient-controlled analgesia significantly more than MGH.
No significant differences were observed in pain reduction, discharge opioid use, hospital length of stay, pulmonary complications, or mortality rates.
Congestive heart failure and chronic obstructive pulmonary disease significantly predicted pneumonia risk.

Resumen

Evidence on non-operative management of multiple single rib fractures remains limited, resulting in institutional treatment variation. This study compared outcomes of different pain management strategies. A retrospective cohort study at Massachusetts General Hospital (MGH, USA) and Leiden University Medical Center (LUMC, The Netherlands) included patients ≥ 18 years with ≥ 3 single rib fractures between 2018 and 2023. Exclusion criteria included flail chest, surgical fixation, severe extra-thoracic trauma, Glasgow Coma Scale < 15 after 72 h, and transfers. Primary outcomes were pain score change, discharge opioid use, and pulmonary complications. Secondary outcomes included mortality and hospital length of stay (HLOS). Subgroup analysis compared fracture side and displacement, and ICU admission. Forward stepwise logistic regression analysis identified predictors of pneumonia. 545 patients were included (109 at LUMC). LUMC patients were younger (61 vs. 68 years, p < 0.001) with fewer comorbidities but higher injury severity scores (13 vs. 10, p < 0.001). LUMC favored patient-controlled analgesia (22.9% vs. 5.7%, p < 0.001) and less provider-controlled opioids (11.0% vs. 21.3%, p < 0.001). Pain score reduction (4 vs. 4, p = 0.68), discharge opioid use (45 vs. 45 oral morphine equivalents, p = 0.75), HLOS (3 vs. 4 days, p = 0.059), pulmonary complications (3.7% vs. 6.2%, p = 0.31), and mortality (2.8% vs. 1.8%, p = 0.54) were similar. Bilateral and displaced fractures required ICU admission more often but had similar outcomes. Congestive heart failure (OR 14.86, 95%CI 3.24–68.16, p = 0.001) and chronic obstructive pulmonary disease (OR 8.08, 95%CI 1.72–38.03, p = 0.008) independently predicted pneumonia. Despite differences in patient characteristics and pain management, outcomes were similar. Hospital level treatment heterogeneity may be acceptable when tailored to patient needs, questioning the need for rigid guidelines.

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