Lactate Dehydrogenase B delactylation promotes gastric cancer metastasis via enhancing glutathione-mediated resistance to ferroptosis

Puntos clave

• This research aims to understand how LDHB-K58 delactylation contributes to gastric cancer metastasis and resistance to treatment.
• Investigated the role of LDHB-K58 delactylation in gastric cancer cells.
• Analyzed SLC7A11-mediated GSH synthesis and its relation to ferroptosis resistance.
• Utilized experimental models to observe metastasis rates in response to delactylation.
• Delactylation of LDHB enhances GSH synthesis, promoting ferroptosis resistance.
• Increased metastasis observed in gastric cancer models due to elevated ferroptosis resistance.
• Targeting this metabolic pathway shows potential as a therapeutic strategy.