What does this research mean for the field?

Clonal evolution in a CALM-AF10 driven AML murine model results in leukemias with distinct genetic and phenotypic diversity. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research explores how clonal evolution in a CALM-AF10 driven AML murine model contributes to genetic and phenotypic diversity.

March 2, 2026Open Access

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Evolution of distinct subclones in a CALM-AF10 driven AML murine model results in leukemias with different phenotypes

NZNiloofar ZandvakiliUniversity of Auckland HLHui Mei LeeUniversity of Auckland RDRhea DesaiUniversity of Auckland

Puntos clave

This research explores how clonal evolution in a CALM-AF10 driven AML murine model contributes to genetic and phenotypic diversity.
Utilized a murine model driven by CALM-AF10 to study AML.
Analyzed genetic variations among developed subclones.
Observed the phenotypic differences in resultant leukemias.
Identified distinct subclones resulting from clonal evolution.
Noted significant genetic diversity among these subclones.
Observed different phenotypes of leukemia linked to specific subclonal compositions.

Resumen

• Clonal evolution in an AML murine model creates genetic and phenotypic diversity, making this a powerful tool to study AML heterogeneity.

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Cite This Study

Zandvakili et al. (Sun,) studied this question.

synapsesocial.com/papers/69a52920f1e85e5c73bf06d5 https://doi.org/https://doi.org/10.1016/j.bneo.2026.100211

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