VEGFA rs699947 C allele carriers had a 20% reduced risk of tendon and ligament injuries (OR 0.80, 95% CI 0.6510-0.98, P=0.03) among athletes.
Elite athletic performance is a complex confluence of genetic predisposition and environmental factors, underscoring the importance of personalized training and injury prevention.
Estimación del efecto: OR 0.80 for reduced injury risk with VEGFA rs699947 C allele (95% CI 0.6510-0.98)
valor p: p=0.03
The presented narrative literature review analyzes the interaction between genetic polymorphisms and environmental factors (training and nutrition) to define athletic performance and risk of injury. Genetic endurance, power, strength and risk of injury, was reviewed in a variety of sports including football, rugby and soccer. Significant genetic polymorphisms were found, such as ACTN3 rs1815739, ACE I/D and VEGFA rs699947, which influence the outcome of the performance and risk of injury. Also the significance of the genetic and environmental interaction, particularly in reaction to nutritional supplementation like iron and caffeine, was highlighted and personal training and nutritional habits were mentioned as crucial in realising the best in athletic performance. Despite high levels of correlation between the genetic factors and the athletic performance, it was apparent that elite performance is a complicated confluence of genetic predisposition and the environment which underscores the importance of treating individuals uniquely as far as training and injury prevention are concerned. The review will require more research in the enhancement of genetic testing technologies and translating them into practice in the field of sports science.
Anosha Altaf (Thu,) conducted a review in Adult athletes aged 18-45 across various sports disciplines including endurance, power, elite, and injury-prone athletes. Genetic polymorphism testing and interaction with environmental factors (training, nutrition) vs. No genetic testing or different genotypes was evaluated on Athletic performance outcomes including endurance, power, strength, injury susceptibility, and training adaptations related to genetic polymorphisms (OR 0.80 for reduced injury risk with VEGFA rs699947 C allele, 95% CI 0.6510-0.98, p=0.03). VEGFA rs699947 C allele carriers had a 20% reduced risk of tendon and ligament injuries (OR 0.80, 95% CI 0.6510-0.98, P=0.03) among athletes.