March 3, 2026Open Access

Hyaluronic acid-coated Poly(L-lactide-co-1,3-trimethylene carbonate) modulate early cellular-scaffold interactions and osteogenic potential: a comprehensive in vitro and in vivo evaluation using mesenchymal stromal cells

Puntos clave

HA coating significantly improves scaffold hydrophilicity and enhances cell adhesion, promoting osteogenic potential.
Key metrics indicate that HA-coated scaffolds increase osteogenic signaling and cellular engagement in early stages.
Observational analysis across in vitro and in vivo settings reveals the influence of scaffold properties on long-term outcomes.
These findings suggest the potential for HA-coated scaffolds in dental biofabrication and bone regeneration, warranting further exploration.

Resumen

HA coating improved scaffold hydrophilicity and promoted early cell adhesion and osteogenic signaling. The findings indicate that HA-coated PLATMC scaffolds support early cellular engagement and osteoconductivity, while long-term outcomes are likely governed by intrinsic scaffold properties. These results highlight the potential of HA-coated PLATMC scaffolds for biofabrication in dentistry, particularly in oral and maxillofacial bone regeneration.

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