The Achilles’ heel of hepatocellular carcinoma: ginsenoside compound K as a novel GPX4 degrader promotes ferroptosis in hepatocellular carcinoma

Puntos clave

• Ginsenoside compound K significantly promotes ferroptosis, enhancing tumor cell death.
• Ferroptosis induced by compound K is linked to decreased GPX4 protein levels, resulting in oxidative stress.
• Assessment using biochemical assays shows marked inhibition of hepatocellular carcinoma cell growth.
• This novel intervention suggests therapeutic potential for hepatocellular carcinoma treatment.