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March 3, 2026
Effects of PFOA and emerging alternatives at environmental concentrations on murine- and human-derived microglia: A comparative study
KW
Keyue Wu
SZ
Shun Zhou
AT
Aoxue Tang
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Puntos clave
Microglia from both murine and human sources show altered function when exposed to PFOA.
PFOA exposure resulted in significant neuroinflammatory responses measured in both models.
Assessment of microglial response utilized both murine- and human-derived cell cultures to improve translational understanding.
Impacts highlight the need for evaluating environmental neurotoxicants in diverse biological setups.
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Effects of PFOA and emerging alternatives at environmental concentrations on murine- and human-derived microglia: A comparative study | Synapse
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Wu et al. (Tue,) studied this question.
synapsesocial.com/papers/69a75a87c6e9836116a20757
https://doi.org/https://doi.org/10.1016/j.envres.2026.123876