Whey and its permeates constitute highly organic, low-alkalinity dairy streams whose management remains suboptimal in many processing facilities. This narrative review integrates recent evidence on the anaerobic digestion (AD) of whey, linking substrate composition and biodegradability with microbial pathways, inhibition mechanisms, biogas quality, and techno-economic and environmental feasibility in industrial settings. Data for sweet whey, acid whey, and their permeates are synthesized, with emphasis on operational windows, micronutrient requirements, and co-digestion or C/N/P/S balancing strategies that sustain resilient methanogenic communities. Options for biogas conditioning and upgrading towards combined heat and power, boiler applications, and compressed or liquefied biomethane are examined, and selection criteria are proposed based on impurity profiles, thermal integration, and methane-recovery performance. Finally, critical R&D gaps are identified, including mechanistic monitoring, bioavailable micronutrition, modular upgrading architectures, and the valorization of digestate as a recovered fertilizer. This review provides an integrated framework to guide the design and operation of technically stable, environmentally verifiable, and economically viable whey-to-biomethane schemes for the dairy industry.
Ramírez-Navas et al. (Tue,) studied this question.