Noninvasive prediction of operational tolerance in liver transplantation based on a peripheral blood transcriptional biomarker panel
Puntos clave
Operational tolerance can be predicted noninvasively using a biomarker panel, indicating promising advances in liver transplantation.
Key evidence includes the potential for safely achieving immunosuppressive (IS) therapy withdrawal in liver transplant recipients.
Assessment utilized a peripheral blood transcriptional biomarker panel to identify the propensity for spontaneous operational tolerance.
The findings support a shift towards noninvasive methods, but external validation is necessary to confirm accuracy and reliability.
Resumen
This model might make it feasible to non-invasively identify the propensity to achieve spontaneous OT among liver recipients undergoing IS therapy and safely achieve IS withdrawal.
Predicción no invasiva de la tolerancia operativa en el trasplante de hígado basada en un panel de biomarcadores transcripcionales en sangre periférica | Synapse