Our research indicates significant differences in the metabolites of A. fumigatus conidial supernatant between the pre-germination and post-germination stages. The conidial supernatant can induce a pronounced inflammatory response in macrophages, mediated by the activation of the JAK/STAT/MAPK pathways. Long-term exposure to spore supernatant in mice can result in pneumonia and tissue damage.
Li et al. (Tue,) studied this question.