The baseline levels of IL-2R were correlated with patient age, nutritional status, and inflammatory response. PNI was associated with tumor burden in patients. Among the 136 patients, the cutoff value for IL-2R was 1,202 U/mL, while the cutoff value for PNI in the 171 patients was 44.65. Patients with high IL-2R and low PNI shared common characteristics, including advanced age, higher Ann Arbor stage, more frequent B symptoms, higher IPI scores, a higher proportion of intermediate-to-high-risk patients, poorer performance status, and shorter overall survival (OS) and progression-free survival (PFS). Multivariate analysis indicated that IL-2R > 1,202 U/mL and PNI ≤ 44.65 were independent risk factors for poor PFS and OS in newly diagnosed DLBCL patients.
Xie et al. (Tue,) studied this question.