March 3, 2026

A multi-rotor near-infrared probe for high-sensitivity imaging of mitochondrial viscosity in epilepsy

Puntos clave

Elevated mitochondrial viscosity is visualized in epileptic neurons and mouse hippocampus in vivo.
Mitochondrial viscosity imaging was achieved using the near-infrared fluorescent probe Cy-TPE.
The TICT-mediated multi-rotor design enhances sensitivity to viscosity changes, supporting detailed imaging capabilities.
Further exploration of mitochondrial viscosity could uncover new insights into epilepsy mechanisms.

Resumen

A mitochondria-targeted near-infrared fluorescent probe (Cy-TPE) is developed for mitochondrial viscosity imaging. A TICT-mediated multi-rotor architecture markedly enhances sensitivity to subtle viscosity changes, while persistent mitochondrial targeting enables long-term imaging. Cy-TPE visualizes elevated mitochondrial viscosity in epileptic neurons and mouse hippocampus in vivo.

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Cite This Study

Zhang et al. (Thu,) studied this question.

synapsesocial.com/papers/69a75b27c6e9836116a21f47 https://doi.org/https://doi.org/10.1039/d6cc00108d

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