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Progression-free survival 2 (PFS2) as a surrogate endpoint for overall survival (OS) in breast cancer randomized controlled clinical trials | Synapse
March 3, 2026
Open Access
Progression-free survival 2 (PFS2) as a surrogate endpoint for overall survival (OS) in breast cancer randomized controlled clinical trials
PF
P. Filis
Karolinska Institutet
NF
N. Filis
University of Ioannina
TF
T. Foukakis
Karolinska University Hospital
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Puntos clave
Progression-free survival 2 shows promise as a surrogate endpoint for overall survival in breast cancer trials.
Analysis includes metrics from multiple studies, highlighting a strong correlation between PFS2 and OS outcomes.
Results are derived from randomized controlled trials which provide a robust framework for evaluation.
Supports the use of PFS2 to assess treatment efficacy, prioritizing patient outcomes in clinical settings.
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Filis et al. (Tue,) studied this question.
synapsesocial.com/papers/69a75b32c6e9836116a22184
https://doi.org/https://doi.org/10.1016/j.esmoop.2026.106062
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