Association between Menopausal Hormone Therapy and Cancer: A Nationwide Retrospective Cohort Study in South Korea

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• Lower-potency progestogens may reduce breast cancer risk while potentially increasing endometrial cancer risk.
• Findings suggest an overall reduction in cancer risk with careful hormone therapy management for menopausal women.
• Observational analysis indicates the balance of hormone therapy efficacy and safety needs reevaluation among women.
• Results highlight the necessity for personalized treatment plans in menopausal hormone therapy to mitigate cancer risks.