Diagnostic Performance of the α-Synuclein Seed Amplification Assay for Dementia With Lewy Bodies | Synapse
March 3, 2026Open Access
Diagnostic Performance of the α-Synuclein Seed Amplification Assay for Dementia With Lewy Bodies
Puntos clave
Diagnostic performance of the α-synuclein seed amplification assay varies significantly among laboratories.
The accuracy rate for distinguishing dementia with Lewy bodies from healthy controls is inconsistent.
Assessment conducted across four laboratories to evaluate the performance of CSF α-synuclein SAA.
Findings highlight the need for standardized procedures in diagnostic tests for DLB to enhance reliability.
Resumen
This study provides Class III evidence of variations in the accuracy of CSF α-syn SAA across 4 separate laboratories in distinguishing patients with DLB from healthy controls.