Vascular smooth muscle cell RNA-binding protein U2AF2 induces copper death by regulating C1qbp expression, delaying development of atherosclerosise

Puntos clave

• Induction of copper death alters atherosclerosis development, affecting vascular smooth muscle cells directly and through the U2AF2-C1qbp axis.
• Targeted inhibition of U2AF2 may delay lesions related to atherosclerosis, providing a new therapeutic angle with implications for treatment.
• Analysis highlights the regulatory relationship between U2AF2 and C1qbp, contributing to significant pathways in atherosclerosis development.
• Copper death mechanisms offer novel insight into the treatment of atherosclerosis, with potential wider applications in vascular health.