Activator protein-1 (AP-1) inhibition prevents endothelial to mesenchymal transition in diabetes-associated atherosclerosis: a translational study

Puntos clave

• Inhibition of AP-1 significantly reduces endothelial to mesenchymal transition, preventing atherosclerosis.
• The treatment led to a notable decrease in atherosclerosis indicators in diabetic models with human serum involved.
• Observational analysis using human serum highlighted the relevancy and potential for clinical application of these findings.
• Implications support further exploration of AP-1 as a therapeutic target in diabetes-related vascular diseases.