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March 3, 2026
Structure and mechanism of the human bile acid transporter OSTα–OSTβ
KW
Ke Wang
JF
Junping Fan
Beijing National Laboratory for Molecular Sciences
HC
Huiwen Chen
Chinese Academy of Sciences
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Puntos clave
The OSTα–OSTβ transporter facilitates bile acid transport across cell membranes, enhancing metabolism.
Key structural features were identified, revealing how the transporter interacts with bile acids.
Analysis involved advanced imaging techniques to elucidate the transporter's function at the molecular level.
Understanding this mechanism supports potential therapeutic targets for metabolic disorders involving bile acids.
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Structure and mechanism of the human bile acid transporter OSTα–OSTβ | Synapse
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Wang et al. (Wed,) studied this question.
synapsesocial.com/papers/69a75c06c6e9836116a2464e
https://doi.org/https://doi.org/10.1038/s41586-025-09934-8