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Psychedelics elicit their effects by 5-HT2A receptor-mediated Gi signalling | Synapse
March 3, 2026
Psychedelics elicit their effects by 5-HT2A receptor-mediated Gi signalling
ZX
Zheng Xu
Sichuan University
HW
Hao Wang
General Cardiology
JY
Jingjing Yu
Sichuan University
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Puntos clave
Psychedelics elicit distinct effects via 5-HT2A receptor pathway mediated Gi signalling, enhancing serotonin function.
Activation of the 5-HT2A receptor initiates Gi signalling, leading to altered neurotransmission dynamics.
The findings indicate potential therapeutic pathways, linking psychedelics and neurological conditions through specific receptor interactions.
Further exploration of 5-HT2A receptor dynamics could yield insights into both psychedelic therapy and brain function.
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Cite This Study
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Xu et al. (Wed,) studied this question.
synapsesocial.com/papers/69a75c3fc6e9836116a24ee6
https://doi.org/https://doi.org/10.1038/s41586-025-10061-7