March 3, 2026Open Access

Hepatitis B virus (HBV) DNA is present as both cccDNA and integrated forms in kidney tissues of HBV surface antigen-negative patients with renal cell carcinoma

Puntos clave

HBV DNA was found in renal cell carcinoma tissues, linking it to potential carcinogenesis.
In this study, 70% of samples showed both cccDNA and integrated forms of HBV DNA in kidney tissues.
Analysis observed the correlation between HBV presence and renal cell carcinoma occurrence among negative HBV surface antigen patients.
Findings imply that HBV may play a direct role in kidney cancer development, warranting further investigation.

Resumen

Intrarenal presence of HBV DNA is a frequently occurring event strongly associated with RCC, suggesting a potential direct role of HBV in renal carcinogenesis.

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Cite This Study

Lombardo et al. (Wed,) studied this question.

synapsesocial.com/papers/69a75c61c6e9836116a2536c https://doi.org/https://doi.org/10.1016/j.ijid.2026.108440

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