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P2X7 Receptor Inhibition Mitigates Microglial Activation, Neuroinflammation, and Secondary Thalamic Damage After Ischemic Stroke | Synapse
March 3, 2026
P2X7 Receptor Inhibition Mitigates Microglial Activation, Neuroinflammation, and Secondary Thalamic Damage After Ischemic Stroke
XW
Xiaomei Wu
MG
Ming Gong
Second Affiliated Hospital of Guangzhou Medical University
LP
Linhui Peng
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Puntos clave
Inhibition of the P2X7 receptor decreases thalamic damage after ischemic stroke, promoting recovery.
Neuroinflammation was mitigated with receptor inhibition, with significant changes noted within 72 hours.
Assessment involved analyzing neuroinflammatory markers post-stroke, highlighting receptor inhibition's protective role.
Findings support the need for clinical strategies targeting the P2X7 receptor to improve ischemic stroke outcomes.
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Cite This Study
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Wu et al. (Thu,) studied this question.
synapsesocial.com/papers/69a75c83c6e9836116a25724
https://doi.org/https://doi.org/10.1007/s12035-026-05665-7