March 3, 2026Open Access

Comparing efficacy and safety of oral drugs in treatment of hyperthyroidism: a systematic review and network meta-analysis

Puntos clave

I-131+LC shows higher efficacy in treating hyperthyroidism compared to other methods, and
I-131+PTU excels in reducing FT3 levels, increasing TSH, and minimizing adverse reactions.
The systematic review involved multiple treatment comparisons through a network meta-analysis approach.
Further multicenter studies are necessary for better validation due to existing quality limitations.

Resumen

This study indicates that among the interventions for treating hyperthyroidism, I-131+LC has a higher efficacy rate compared to other treatments, I-131+PTU is superior in reducing FT3, increasing TSH and reducing adverse reactions compared to other treatments. Due to the limitations in the quantity and quality of the included studies, the aforementioned conclusions await further validation from more large-sample, high-quality, and multicenter studies. PROSPERO study number CRD42024566298.

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