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Rational design of novel procaspase-3 activators for the targeted therapy of triple-negative breast cancer | Synapse
March 3, 2026
Rational design of novel procaspase-3 activators for the targeted therapy of triple-negative breast cancer
ZG
Z M Guo
HL
Huan Liu
CM
Chenxiaoning Meng
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Puntos clave
Targeted therapy using novel procaspase-3 activators effectively engages caspase pathways.
In vitro studies demonstrate a 40% increase in procaspase-3 activation in treated cancer cells.
Analysis of molecular interactions underscores the novel design of procaspase-3 activators.
Highlighting the need for further clinical validation in triple-negative breast cancer treatments.
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Guo et al. (Wed,) studied this question.
synapsesocial.com/papers/69a75cb8c6e9836116a25d28
https://doi.org/https://doi.org/10.1016/j.bioorg.2026.109569