For the first time, conditions have been found under which a unique combination of anticancer properties of Keggin heteropoly acids (KHPA) and their simplest salts is observed – high and selective cytotoxic activities (at the level of IC 100 μM and IS 3). To describe the nature of the observed dependencies, a molecular model of pore formation in bilayer lipid membranes by multiply charged anions was proposed. Analysis of the consequences arising from the proposed model led to the conclusion about the possibility of increasing the anticancer activity of KHPA by increasing their anionic charges.
F. I. Dalidchik (Wed,) studied this question.