PTPN11-Related Noonan Syndrome Predisposes to Multifocal Low-Grade CNS Tumors Harboring FGFR1 Variants

Puntos clave

• Multifocal low-grade CNS tumors are more common in patients with PTPN11-related Noonan syndrome, indicating a notable predisposition.
• Increased incidence of CNS tumors was linked to FGFR1 variants, enhancing the understanding of genetic influences on tumor development.
• Assessment of patients with Noonan syndrome showed significant patterns of tumor development, providing insights into associated risk factors.
• Findings highlight the need for genetic screening in the Noonan syndrome population, emphasizing potential preventive strategies.