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Oncolytic peptide LTX-315 targets PD-L1 to improve antitumor immune response of nanosecond pulse electric field in liver cancer | Synapse
March 3, 2026
Open Access
Oncolytic peptide LTX-315 targets PD-L1 to improve antitumor immune response of nanosecond pulse electric field in liver cancer
KJ
Kun Ji
Pancreas Centre (Canada)
JL
Jing Li
First Affiliated Hospital Zhejiang University
TX
Tiantian Xu
Nanchang University
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Puntos clave
Antitumor immune response improves with LTX-315 treatment in liver cancer patients, indicating strong potential.
LTX-315 targets the PD-L1 pathway, enhancing the efficacy of the nanosecond pulse electric field.
Assessment using nanosecond pulse electric field facilitates improved immune activation against liver cancer.
Implications highlight that targeting PD-L1 with LTX-315 may enable better liver cancer therapies in clinical settings.
Resumen
LTX-315; Antitumor immune response; nsPEF; Liver cancer.
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Ji et al. (Thu,) studied this question.
synapsesocial.com/papers/69a75d0ec6e9836116a267be
https://doi.org/https://doi.org/10.1136/jitc-2025-012438
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