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Endothelial USP8 is essential for angiogenesis | Synapse
March 3, 2026
Open Access
Endothelial USP8 is essential for angiogenesis
AP
Alba Pau-Navalón
Instituto de Salud Carlos III
TG
Tamara González-Costa
Centro de Investigación en Red en Enfermedades Cardiovasculares
ML
María Lancho Lavilla
Technical University of Munich
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Puntos clave
Endothelial USP8 is essential for angiogenesis, influencing vascular development and integrity.
Significant findings demonstrate that disruption of USP8 impairs blood vessel formation in experimental models.
Analysis of endothelial cell behavior reveals the involvement of USP8 in critical molecular pathways driving angiogenesis.
Understanding USP8's role may open new avenues for targeting vascular-related diseases, emphasizing potential therapeutic strategies.
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Pau-Navalón et al. (Wed,) studied this question.
synapsesocial.com/papers/69a75d1ec6e9836116a269e7
https://doi.org/https://doi.org/10.1007/s10456-025-10027-3