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March 3, 2026
Open Access
The host RNA helicase DDX6 restricts avian influenza virus replication by targeting viral NP and modulating ISG15
XL
Xiaolong Lu
Yangzhou University
CL
Chenyu Lu
Yangzhou University
MH
Mengyang He
Yangzhou University
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Puntos clave
Viral replication is significantly restricted by the action of DDX6 on viral NP and ISG15 modulation.
The study found that DDX6 reduces viral NP levels and affects immune response pathways.
Analysis of antiviral mechanisms highlighted DDX6’s role in enhancing host defense against avian influenza.
Further work is needed to explore DDX6 as a therapeutic target in treating influenza infections.
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The host RNA helicase DDX6 restricts avian influenza virus replication by targeting viral NP and modulating ISG15 | Synapse
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Lu et al. (Wed,) studied this question.
synapsesocial.com/papers/69a75d24c6e9836116a26b1f
https://doi.org/https://doi.org/10.1016/j.psj.2026.106529