Partition coefficient for pharmaceutical applications: measurements and simulations.

Puntos clave

• The partition coefficient significantly influences drug solubility and bioavailability in pharmaceutical applications.
• Accurate measurements and simulations of the partition coefficient are crucial for effective drug development and formulation.
• Experimental measurements were complemented by simulations to analyze partition coefficient variations across various compounds.
• Findings highlight the importance of optimizing the partition coefficient to enhance therapeutic efficacy and safety.