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Risk Factors for Falls in Older Depressed Adults Treated with Bupropion: An Analysis of the OPTIMUM Randomized Clinical Trial | Synapse
March 3, 2026
Risk Factors for Falls in Older Depressed Adults Treated with Bupropion: An Analysis of the OPTIMUM Randomized Clinical Trial
DB
David A. Bender
Washington University in St. Louis
BP
Bruce G. Pollock
Albany State University
HL
Helen Lavretsky
University of California, Los Angeles
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Puntos clave
Falls were significantly associated with increased depression severity, impacting treatment outcomes.
A 25% increase in fall risk was observed among those treated with bupropion compared to other treatments.
Analysis of the OPTIMUM randomized clinical trial data revealed key risk factors for falls among participants.
Identifying these risks may improve safety protocols for older adults undergoing treatment for depression.
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Cite This Study
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Bender et al. (Thu,) studied this question.
synapsesocial.com/papers/69a75d75c6e9836116a27867
https://doi.org/https://doi.org/10.1007/s11606-026-10181-4