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March 3, 2026
Phosphorylation-dependent STAMBP drives the progression of pancreatic ductal adenocarcinoma by deubiquitinating and stabilizing BAG3
YS
Yongkang Shi
Tongji Hospital
JG
Jun Gong
LC
Lin Chen
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Puntos clave
Pancreatic ductal adenocarcinoma progression is driven by STAMBP's activity on BAG3, enhancing stability.
Findings indicate that STAMBP facilitates deubiquitination of BAG3, contributing to cancer advancement.
The analysis employed phosphorylation-dependent mechanisms to understand the role of STAMBP in cancer biology.
These insights may enable targeted therapies focusing on the STAMBP-BAG3 interaction for pancreatic cancer treatment.
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Shi et al. (Thu,) studied this question.
synapsesocial.com/papers/69a75d89c6e9836116a27ad9
https://doi.org/https://doi.org/10.1038/s41418-026-01665-1
Phosphorylation-dependent STAMBP drives the progression of pancreatic ductal adenocarcinoma by deubiquitinating and stabilizing BAG3 | Synapse