March 3, 2026Open Access

Analysis of comorbid characteristics, molecular mechanisms between mild cognitive impairment and Alzheimer’s disease with interventions in a community-based population in Shanghai

Puntos clave

Mild cognitive impairment patients are at high risk of Alzheimer's disease, highlighting urgent intervention needs.
Intervention with boldine and piceatannol may offer potential benefits in cognitive function based on identified comorbidities.
Observational analysis in a community-based population reveals the impact of lifestyle factors on cognitive impairment.
Findings support early intervention strategies to prevent the progression from mild cognitive impairment to Alzheimer's.

Resumen

MCI patients in the community are at high risk of AD, and their comorbidity characteristics are affected by multidimensional lifestyle and psychological factors. Boldine and piceatannol may be potential natural compounds for the intervention of cognitive impairment. The results of this study can provide a theoretical basis for the early prevention and precise intervention of cognitive impairment in the community.

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