Chronic co-exposure to BPA and alcohol synergizes hepatotoxicity via dysregulation of glycerolipid metabolism and ceramide/HtrA2-driven apoptosis in HepG2 cells | Synapse
March 3, 2026
Chronic co-exposure to BPA and alcohol synergizes hepatotoxicity via dysregulation of glycerolipid metabolism and ceramide/HtrA2-driven apoptosis in HepG2 cells
Puntos clave
Hepatotoxicity increased in HepG2 cells due to combined exposure to BPA and alcohol, indicating significant metabolic disruptions.
Glycerolipid metabolism was notably dysregulated, highlighting its role in the observed toxic effects from co-exposure.
Utilizing HepG2 cells, the analysis focused on ceramide pathways and HtrA2-driven apoptosis associated with exposure.
These findings may emphasize the risks of combining BPA with alcohol, stressing the need for further research on public health implications.