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Decreased within-default mode network connectivity with accelerated intermittent theta burst stimulation across unipolar and bipolar depression: Candidate transdiagnostic circuit marker for treatment response | Synapse
March 3, 2026
Open Access
Decreased within-default mode network connectivity with accelerated intermittent theta burst stimulation across unipolar and bipolar depression: Candidate transdiagnostic circuit marker for treatment response
YS
Yvette I. Sheline
University of Pennsylvania
AB
Alexandra S. Batzdorf
University of Pennsylvania
WM
Walid Makhoul
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Puntos clave
Decreased connectivity in the default mode network indicates potential treatment effects of theta burst stimulation.
Connectivity levels were notably reduced, particularly in patients with unipolar and bipolar depression.
This analysis employed observed changes following accelerated intermittent theta burst stimulation for treatment.
Significance highlights the need for further exploration of network markers in managing different depressive disorders.
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Sheline et al. (Thu,) studied this question.
synapsesocial.com/papers/69a75ddcc6e9836116a2825b
https://doi.org/https://doi.org/10.1016/j.transm.2026.100205