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Enhancing adoptive T cell therapy by disrupting the SKI-SMAD2/3 axis to counteract TGF-β-mediated immunosuppression | Synapse
March 3, 2026
Enhancing adoptive T cell therapy by disrupting the SKI-SMAD2/3 axis to counteract TGF-β-mediated immunosuppression
XJ
Xiaohan Jin
North Sichuan Medical University
JY
Jinmei Yu
Harbin Medical University
XW
Xinyu Wu
North Sichuan Medical University
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Puntos clave
Immunosuppression is significantly reduced by disrupting the SKI-SMAD2/3 axis, enhancing therapy effectiveness.
Key evidence indicates that targeting TGF-β improved T cell responses under immunosuppressive conditions.
Analysis involved mechanisms of adoptive T cell therapy and the SKI-SMAD2/3 signaling pathway.
Success in this approach suggests a potential advancement for cancer treatments, highlighting a new direction in therapy.
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Cite This Study
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Jin et al. (Thu,) studied this question.
synapsesocial.com/papers/69a75dffc6e9836116a2854b
https://doi.org/https://doi.org/10.1016/j.ymthe.2026.01.028