Activation of PBK by Gal-3 contributes to pulmonary artery hypertension by promoting PRC1 activation

Puntos clave

• PRC1 activation contributes significantly to pulmonary artery hypertension development.
• Galectin-3 levels correlate with increased PBK and PRC1 activation, suggesting a pathway for intervention.
• Assessment of PBK and PRC1 activation in pulmonary artery hypertension was conducted using specific molecular assays.
• Study results may enable new treatment options for pulmonary artery hypertension based on galectin-3 modulation.