Macrophage-derived S100A9 drives liver fibrosis in Echinococcus multilocularis infection by up-regulating secreted protein acidic and rich in cysteine (SPARC) in hepatic stellate cells

Puntos clave

• Liver fibrosis is driven by macrophage-derived S100A9 during Echinococcus multilocularis infection, affecting liver health.
• S100A9 significantly up-regulated the secreted protein acidic and rich in cysteine (SPARC), contributing to fibrotic changes in liver cells.
• Assessment involved cellular interactions between macrophages and hepatic stellate cells in response to parasitic infection.
• Targeting S100A9 may help develop new treatments for liver fibrosis linked to Echinococcus multilocularis.