Fuzheng Shengbai decoction enhances antitumor immunity via YTHDC2-dependent stabilization of CLCA2 mRNA in colorectal cancer
Puntos clave
Enhanced CD8+ T-cell activation indicates improved anti-colorectal cancer responses with FZSB treatment.
A key mechanism involves the YTHDC2-CLCA2 axis through m6A-mediated mRNA stabilization.
Fuzheng Shengbai decoction identifies a promising therapeutic avenue for colorectal cancer.
Further research is required to validate these findings and explore clinical applications.
Resumen
FZSB enhances anti-colorectal cancer immune responses and is associated with increased CD8+ T-cell activation, while concurrently modulating the YTHDC2-CLCA2 axis via m6A -mediated mRNA stabilization.