Vaginal tamoxifen – A potential treatment option for vaginal atrophy symptoms in postmenopausal women who cannot use estrogen

Puntos clave

• More than two-thirds of women reported relief from troublesome vaginal atrophy symptoms with tamoxifen use, showing its potential effectiveness.
• Evidence indicates that tamoxifen's estrogen agonistic effects in the vagina may play a key role in these improvements under low-estrogen conditions.
• This observational analysis highlights the need for improved vaginal administration techniques to enhance treatment effects.
• Endometrial safety concerns remain, emphasizing the necessity for further studies to address potential risks.