March 3, 2026Open Access

CD4+ T cell dysregulation in major depressive disorder is associated with sleep disturbance

Puntos clave

Patients with major depressive disorder and sleep disturbances show elevated CD4+ T cells compared to those without.
The proportion of CD4+ T cells can indicate a dysregulated immune response associated with depression.
Targeted interventions for sleep disruption may help restore immune homeostasis in these patients.
Results suggest a novel therapeutic strategy for managing major depressive disorder through sleep improvement.

Resumen

Our findings demonstrate that patients with MDD comorbid with sleep disturbances exhibit elevated proportions of CD4+ T cells compared to those without such disturbance. These results suggest that targeted interventions addressing sleep disruption may contribute to restoring CD4+ T cell homeostasis, potentially offering a novel therapeutic strategy for MDD management.

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