Tumor-associated macrophage-specific LRRFIP1 promotes M2 macrophage polarization and progression of colorectal cancer via activation of the PI3K pathway | Synapse
March 3, 2026Open Access
Tumor-associated macrophage-specific LRRFIP1 promotes M2 macrophage polarization and progression of colorectal cancer via activation of the PI3K pathway
Puntos clave
M2 macrophage polarization correlates with tumor progression, indicating an aggressive cancer phenotype.
Activation of the PI3K pathway is significantly involved in this polarization process, influencing cancer dynamics.
The study's findings suggest that targeting LRRFIP1 may provide new therapeutic options for managing colorectal cancer.
Further research is needed to confirm these findings and explore the therapeutic implications for patients.