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3 months vs 12 months of romosozumab for postmenopausal osteoporosis (LIDA): an open-label, non-inferiority, randomised controlled trial | Synapse
March 3, 2026
3 months vs 12 months of romosozumab for postmenopausal osteoporosis (LIDA): an open-label, non-inferiority, randomised controlled trial
BL
Benjamin Z Leder
Massachusetts General Hospital
SR
Sabashini K. Ramchand
Cleveland Clinic Lerner College of Medicine
MJ
Mackenzie Jordan
Massachusetts General Hospital
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Puntos clave
Romosozumab effectively increases bone mineral density in postmenopausal women with osteoporosis after both 3 and 12 months of treatment.
The primary outcome measure includes a non-inferiority analysis based on bone mineral density changes at 12 months.
Randomised controlled trial format allowed for direct comparison of treatment durations for effectiveness and safety.
This study highlights the potential for shorter treatment durations, indicating better patient compliance possibly.
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Cite This Study
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Leder et al. (Thu,) studied this question.
synapsesocial.com/papers/69a75e6dc6e9836116a29056
https://doi.org/https://doi.org/10.1016/s2213-8587(25)00319-5