Chemoproteomics-based profiling elucidates the antimalarial effects of amodiaquine through disruption of glycolysis process in Plasmodium falciparum

Puntos clave

• Amodiaquine effectively disrupts glycolysis, leading to significant antimalarial effects.
• The study utilizes chemoproteomics to profile interactions impacting metabolic pathways in Plasmodium falciparum.
• Findings indicate a strong connection between glycolysis inhibition and antimalarial efficacy of amodiaquine.
• The disruption of glycolysis by amodiaquine offers insights into potential new treatment approaches for malaria.