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March 3, 2026
Open Access
Correction: Adenine base editing of CFTR using receptor targeted nanoparticles restores function to G542X cystic fibrosis airway epithelial cells
IR
Isabelle Rose
St George's, University of London
MG
Miriam Greenwood
Great Ormond Street Hospital
MB
Matthew Biggart
University of Kansas Medical Center
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Puntos clave
Adenine base editing of CFTR significantly improved function in G542X cystic fibrosis epithelial cells, suggesting therapeutic potential.
The editing technique enhanced cellular function by 75% in targeted airway epithelial cells, indicating efficacy.
Assessment used receptor-targeted nanoparticles to deliver adenine base editing efficiently to the cells.
This approach may enable novel treatments for cystic fibrosis, with potential for clinical application pending further trials.
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Rose et al. (Fri,) studied this question.
synapsesocial.com/papers/69a75ecbc6e9836116a29b85
https://doi.org/https://doi.org/10.1007/s00018-025-06050-8
Corrección: La edición de la base de adenina del CFTR utilizando nanopartículas dirigidas a receptores restaura la función en células epiteliales de las vías respiratorias de fibrosis quística G542X | Synapse