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Sophoridine alleviates spleen injury in sepsis by inhibiting ASK1-mediated inflammation, oxidative stress, and apoptosis | Synapse
March 3, 2026
Sophoridine alleviates spleen injury in sepsis by inhibiting ASK1-mediated inflammation, oxidative stress, and apoptosis
SZ
S. Zhang
HS
Huilin Sun
XL
X. Z. Li
Xuzhou Medical College
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Puntos clave
Sophoridine effectively reduces markers of spleen injury and oxidative stress in sepsis.
Key metrics show a significant decrease in ASK1 activation and inflammation markers after sophoridine treatment.
The study utilizes an observational analysis focusing on sepsis-induced spleen damage and related mechanisms.
Findings support the potential of sophoridine as a beneficial intervention in sepsis, warranting further exploration.
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Zhang et al. (Fri,) studied this question.
synapsesocial.com/papers/69a75ed3c6e9836116a29c5f
https://doi.org/https://doi.org/10.1016/j.ejphar.2026.178593