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Smart hypoxia-responsive sulfated polysaccharides liposomes for controlled and targeted urokinase delivery in thrombotic therapy | Synapse
March 3, 2026
Smart hypoxia-responsive sulfated polysaccharides liposomes for controlled and targeted urokinase delivery in thrombotic therapy
DW
Dingfu Wang
University of Electronic Science and Technology of China
DL
Dan Li
North University of China
XL
Xiaolin Liu
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Puntos clave
Controlled delivery of urokinase using smart liposomes enhances therapeutic outcomes, especially in hypoxic conditions.
The liposomes are designed to respond to low oxygen levels, releasing urokinase specifically where needed most.
Analysis involves a novel approach using hypoxia-responsive sulfated polysaccharides to improve drug efficacy.
The findings highlight the potential for advanced thrombotic therapy strategies, with implications for improving patient outcomes.
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Wang et al. (Sat,) studied this question.
synapsesocial.com/papers/69a75edac6e9836116a29d08
https://doi.org/https://doi.org/10.1016/j.jconrel.2026.114669